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In the present article, we give a review of modern data and latest achievements pertaining to the study of electronic properties of oxygen vacancies in hafnium oxide. Hafnium …
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This study compares HfO2 ceramics synthesized using sol–gel and combustion methods, emphasizing the impact of the method of synthesis on the resulting properties of the material. The research findings illustrate morphological differences between sol–gel and combustion-derived HfO2. While sol–gel samples displayed …
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In this study, hafnium oxide nanoparticles were designed that concentrate in tumor cells to achieve intracellular high-energy dose deposit. Materials & methods: Conventional methods were used, implemented in different ways, to explore interactions of these high-atomic-number nanoparticles and ionizing radiation with biological systems.
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Hafnium oxide (hafnia, HfO2), due to their photo-luminescence, high atomic number, electron density, and chemical stability, potentiates its application as a radiosensitizing agent for radiation therapy, while exhibiting chemical inertness in cellular and subcellular systems [125]. ... Saliva diagnostics: emerging techniques and biomarkers for ...
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@article{Wei2023PDL1AD, title={PD-L1 aptamer-functionalized degradable hafnium oxide nanoparticles for near infrared-II diagnostic imaging and radiosensitization}, author={Min Wei and Xiao Shen and Xueqi Fan and Jiwei Li and Jingwen Bai}, journal={Frontiers in Bioengineering and Biotechnology}, year={2023}, …
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NBTXR3/Hensify is a 50 nm crystalline hafnium oxide nanoparticle with negatively charged phosphate coating, ... Intravenous nanoparticle therapies and diagnostics which are not clinically approved and are currently undergoing clinical trials (not yet recruiting, recruiting, enrolling by invitation, or active)
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Hafnium oxide (HfO2) is widely recognized as one of the most promising high-k dielectric materials due to its remarkable properties such as high permittivity, wide band gap, and excellent thermal and chemical stability. The atomic layer deposition (ALD) of HfO2 has attracted significant attention in recent decades since it enables uniform …
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High-k dielectrics, such as hafnium oxide (HfO(2)), have the known ability to address these challenges by passivating the exposed surfaces against destabilizing concerns of ion transport. With these fundamental stability issues addressed, a promising target for POC diagnostics and SiNWFETs has been small oligonucleotides, more …
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The recent work from our group has demonstrated that oxygen content has a greater impact than grain size on phase composition and electrical properties of pure hafnium oxide films deposited via reactive pulsed DC magnetron sputtering. 68 Films deposited from a hafnium metal target with oxygen content in the vacuum chamber …
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Hafnium(IV) oxide. CAS 1. Molecular Weight 210.49. Browse Hafnium(IV) oxide and related products at Merck.
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Tetrakis (ethylmethylamino) hafnium (TEMAHf) and ozone (O 3) were used to form the hafnium oxide layer at 350 °C. The gas pressure was 0.7 Torr. The gas pressure was 0.7 Torr.
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Hafnium oxide (HfO 2) is a versatile material with applications in areas ranging from the high-temperature extreme environments of refractory ceramics 1 to sensitive structures for microelectronics. 2 As a high-k dielectric, 3 it has been well established that HfO 2 is capable of enhancing the performance of transistors 4 and …
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NBTXR3 is also in clinical trials for the treatment of other types of cancer (Supplemental Table 2). Hafnium is a high-atomic-number element and (like gadolinium) has a strong photoelectric absorption coefficient, which causes hafnium oxide nanoparticles to display both strong radiosensitizing properties and strong CT contrast.
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In this study, we created PD-L1 aptamer-anchored spherical nucleic acids (SNAs) with a shell made of PD-L1 aptamer and indocyanine green (ICG) embedded in a mesoporous …
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Frontiers in Bioengineering and Biotechnology (Jun 2023) . PD-L1 aptamer-functionalized degradable hafnium oxide nanoparticles for near infrared-II diagnostic imaging and radiosensitization
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This review will cover: 1) Classification and synthesis of Hafnium-based nanomaterials including Hafnium oxide nanomaterials, Hafnium Metal-Organic Frameworks/nanoscale coordination polymers (MOFs/NCPs); 2) Hafnium-based nanomaterials act as contrast …
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Preliminary results suggest a predictable in vitro biological effect of NBTXR3 nanoparticles exposed to ionizing radiation. BackgroundHafnium oxide, NBTXR3 nanoparticles were designed for high dose energy deposition within cancer cells when exposed to ionizing radiation. The purpose of this study was to assess the possibility of predicting in vitro the …
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The construction of degradable hafnium oxide particles to target tumor tissues throughout the body is a promising drug delivery method with improved biosafety. Herein, we …
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Fig. 1 shows an XPS survey scan of a hafnium oxide film. The scan shows sharp lines due to the main constituents (Hf and O) and the carbon C 1s peak arising from hydrocarbon contamination. Fig. 2 is a typical XPS core level spectrum of hafnium oxide thin films in the O 1s region. The C 1s peak, at a binding energy (BE) of 284.6 eV, was …
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This report will describe the status of a project to develop in situ diagnostics for hafnium oxide ALD processes. The focus is on an examination of the utility of Fourier transform …
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Hafnium oxide, like other oxides, is a material with a wide range of homogeneity and its properties are largely dependent on stoichiometry. Therefore, oxygen vacancies have a …
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A team of scientists from the Department of Energy's Oak Ridge National Laboratory has investigated the behavior of hafnium oxide, or hafnia, because of its potential for use in novel semiconductor applications. Materials like hafnia display ferroelectricity, meaning they can store data for extended periods even without power.
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The clinical translation of hafnium oxide for cancer radiotherapy has aroused extensive interest on Hf-based nanomaterials for biomedical application. In article number 2300341, Gan Tian, Wenyan Yin, and co-workers comprehensively summarize the recent advances in synthesis, computed tomography (CT)-involved diagnosis and radiotherapy-related ...
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This report will describe the status of a project to develop in situ diagnostics for hafnium oxide ALD processes. The focus is on an examination of the utility of Fourier transform …
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Chromium (Cr), silver (Ag) and hafnium oxide (HfO2) are used in a surface plasmon resonance (SPR)-based biosensor with an optimized design for measuring blood groups at a wavelength of 633 nm. A buffer layer was placed on the SPR active metal in this investigation to avoid oxidation and contamination of blood samples. A theoretical model …
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This research aimed to compare the quantitative imaging attributes of synthesized hafnium oxide nanoparticles (NPs) derived from UiO-66-NH2(Hf) and two gadolinium- and iodine-based clinical contrast agents (CAs) using cylindrical phantom. Aqueous solutions of the studied CAs, containing 2.5, 5, and 10 mg/mL of HfO2NPs, …
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Atherothrombosis is the main cause of death worldwide. An early diagnosis of this pathology is necessary to avoid serious clinical events. In this study, we report hafnium oxide nanoparticles (HfO2...
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PD-L1 aptamer-functionalized degradable hafnium oxide nanoparticles for near infrared-II diagnostic imaging and radiosensitization Min Wei1,2,3,4,5, Xiao Shen1,2,3,4,5, Xueqi Fan1,2,3,4,5, Jiwei Li6 and Jingwen Bai1,2,3,4,5,7* 1Cancer Center and Department of Breast and Thyroid Surgery, Xiang'an Hospital of Xiamen University, …
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Hafnium oxide is an outstanding candidate for next-generation nonvolatile memory solutions such as OxRAM (oxide-based resistive memory) and FeRAM (ferroelectric random access memory). A key parameter for OxRAM is the controlled oxygen deficiency in HfO2-x which eventually is associated with structural changes. Here, we expand the …
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The colloidal stability, cytotoxicity, and cellular uptake of hafnium oxide (HfO 2) nanoparticles (NPs) were investigated in vitro to assess safety and efficacy for use as a deliverable theranostic in nanomedicine.Monoclinic HfO 2 NPs, ~60-90 nm in diameter and ellipsoidal in shape, were directly prepared without calcination by a hydrothermal …
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The clinical translation of hafnium oxide (HfO 2), commercially namedas NBTXR3, as a new kind of nanoradiosensitizer for radiotherapy (RT) of cancers has aroused extensive interest in researches on Hf-based nanomaterials for biomedical application. In the past 20 years, Hf-based nanomaterials have emerged as potential …
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In previous studies on RT, hafnium has proven as a potential biomaterial [23,26, 36]. Functionalized hafnium oxide nanoparticles (NBTXR3) have been synthesized to increase the effects of RT . Hafnium-based nanoparticles are potent contrast enhancement agents for imaging in cancer. They are also used for liquid biopsy in …
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The interaction of hafnium oxide (HfO2) nanoparticles (NPs) with X-ray and mid-infrared radiation was investigated to assess the potential as a multifunctional diagnostic probe for X-ray computed tomography (CT) and/or mid-infrared biosensing. HfO2 NPs of controlled size were prepared by a sol-gel p …
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Download Citation | PD-L1 aptamer-functionalized degradable hafnium oxide nanoparticles for near infrared-II diagnostic imaging and radiosensitization | Immune checkpoint blockade is now ...
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Scientists and engineers have been pushing for the past decade to leverage an elusive ferroelectric material called hafnium oxide, or hafnia, to usher in the next generation of computing memory. A ...
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