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High throughput screening (HTS) technology is a powerful platform for drug screening with the characteristics of automatic operation, rapid detection, molecular/cellular level, …
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High-throughput screening (HTS) is a key process used in drug discovery to identify hits from compound libraries that may become leads for medicinal chemistry optimization. …
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High-throughput screening (HTS) is a well-established process for lead discovery in Pharma and Biotech companies and is now also being used for basic and applied research in academia. It comprises the screening of large chemical libraries for activity against biological targets via the use of automation, miniaturized assays and …
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This article reviews the origin and evolution of high throughput screening (HTS) through the experience of an individual pharmaceutical company, revealing some of the mysteries of the early stages of drug discovery to the wider pharmacology audience.
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High-throughput screening (HTS) has been postulated in several quarters to be a contributory factor to the decline in productivity in the pharmaceutical industry. Moreover, it has been blamed for ...
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High Throughput Screening (HTS) HTS is approach for identifying potential drug candidates by the rapid evaluation of a large number of compound based on a lead …
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In High Throughput Screening: Methods and Protocols, Second Edition, experts in the field fully update the previous edition to best serve as an introduction to HTS for scientists who are just entering the field, and as a provider of key, significant detail so as to be useful to scientists in established HTS operations. Featuring new screening ...
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The goal of the High-Throughput Screening (HTS) facility is to provide screening-based services to aide research investigators in the identification and investigation of new compounds for basic research and pharmacological discovery. We are equipped to guide investigators through the drug discovery process from assay conception to lead …
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High-throughput screening (HTS) can reduce the attrition of candidate drugs. This methodology exploits new technologies such as robotics, data processing/control …
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High-throughput screening (HTS) has become an important part of drug discovery at most pharmaceutical and many biotech-nology companies worldwide, and use of HTS technologies is expanding into new areas. Target validation, assay development,
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High throughput screening (HTS) plays a crucial role in lead-generation and is well established in the preclinical discovery process of pharmaceutical companies [1,2]. Although primary screening is more than just a 'large numbers game', it does involve the rapid testing of large numbers of compounds (10,000 to 2 million), placing special ...
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High throughput screening (HTS) is routinely used to identify bioactive small molecules. This requires physical compounds, which limits coverage of accessible chemical space. Computational ...
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Collins et al. 5 write that the integration of in vitro high-throughput screening (HTS) into chemical decision-making may transform "toxicology from a predominantly observational science at the ...
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The concept of high-throughput screening (HTS) first appeared in the mid-1980s and has evolved over the past 25 years to serve the changing needs of pharmaceutical research. Sometimes unjustly derided as "antiintellectual," HTS now forms one of the cornerstones of modern small-molecule drug discovery sitting at the interface …
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High-Throughput Screening (HTS) and Fragment-Based Drug Discovery (FBDD) Learn why early-phase drug discovery should not be like looking for a needle in a haystack! Watch now. Resources Chemicals Learning Center—Discover laboratory chemicals resources such as application guides, webinars and events, and more.
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The proposed HTS assay is tested using positive and negative controls to determine the Z' for the assay. The dry run should use the HTS protocol, including SMDC robotics and plate readers where appropriate. When Z' is consistently > 0.5, pilot screening can proceed. 4. Pilot screen. Approximately 2,000 compounds are run using the HTS …
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Definition. HTS is a translational research technology used for identifying effectors (compounds, peptides, and biologics) that modulate target-specific biochemical or cell …
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Recently, the rapid progress in developing functional assays and instrumentation has enabled high throughput screening (HTS) campaigns on an expanding list of channel types. Consequently, HTS …
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The rapid testing of chemical libraries for biological activity is the primary aim of high throughput screening (HTS). Advances in HTS have paralleled those in molecular biology, instrumentation and automation, and informatics, and the increased availability of arrayed compound libraries. Sophisticated high sensitivity assays and the …
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This has identified the need to screen larger libraries where the use of efficient high-throughput screening (HTS) becomes key in the discovery process. HTS can investigate hundreds of thousands of compounds per day. However, if fewer compounds could be screened without compromising the probability of success, the cost …
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High-throughput screening (HTS) is a process of testing a large number of compounds, typically multiple tens of thousands of compounds, in a short period of time to identify those compounds that modulate the activity of the biological target. …
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High throughput screening (HTS) relies on liquid handling devices, robotics, plate readers, and data processing software to automatically test a large number of biological, …
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High Throughput Screening (HTS) Homogeneous and separation-free well plate biochemical assay platforms include proximity-based assays such as scintillation proximity assay (SPA), LOCI (luminescent oxygen channeling assay (i.e. alpha-screen), and fluorescent resonance energy transfer, FRET). ... High throughput ion channel …
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High-throughput screening (HTS) assays enable the testing of large numbers of chemical substances for activity in diverse areas of biology. The biological responses measured in HTS assays span ...
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New technologies in high-throughput screening have significantly increased throughput and reduced assay volumes. Key advances over the past few years include new fluorescence methods, detection platforms and liquid-handling technologies. ... has fueled an important need for improvements in high-throughput screening (HTS) …
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High-throughput screening (HTS) of chemical compounds to identify modulators of molecular targets is a mainstay of pharmaceutical development. Increasingly, HTS is being used to identify chemical p...
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Developing effective high-throughput screening (HTS) methods is of paramount importance in the early stage of drug discovery. While rugged and robust assays may be easily developed for certain ...
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High throughput screening (HTS) relies on liquid handling devices, robotics, plate readers, and data processing software to automatically test a large number of biological, genetic, chemical, or pharmacological samples.
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To ensure that high-throughput screening (HTS) output will be as fruitful as possible requires the collaboration and (often) early intervention of medicinal chemists trained in the art and science of HTS triage. Typically, industry has centralized these early stages of drug discovery into groups like the Lead Discovery Group at the former ...
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High-throughput screening (HTS) assays enable the testing of large numbers of chemical substances for activity in diverse areas of biology. The biological responses measured in HTS assays span ...
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Automation is a critical component of HTS, as speed, throughput, and the production of high-quality data are important. HTS is the process of screening large numbers of biological modulators against selected targets. HTS systems are used to screen different types of libraries such as chemical, genomics, protein, and peptide libraries.
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High-throughput screen (HTS): Iterative testing of different substances in a common assay. Screen is generally considered high throughput for > 10,000 wells per day. Ultra HTS …
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